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KMID : 0603519970020020122
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Journal of Korean Association of Cancer Prevention
1997 Volume.2 No. 2 p.122 ~ p.130
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Variability of the Adaptive Response to Ionizing Radiation Depending on Normal or Neoplastic Properties of the Cells
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Park Sang-Hee
Lee Yeon-Hee
Yoo Seong-Yul
Cho Chul-Koo
Lee Yun-Sil
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Abstract
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Since the beneficial effects induced by low-dose radiation (0.01 ∼ 0.5 Gy) was usually certified in normal cells, we compared the induction of adaptive responses of different properties of the cells: normal mouse lymphocytes (NL); L929 cells established from mouse connective tissue; primary mouse keratinocytes (PK); v-rasHa trasnformed mouse keratinocytes (ras-PK); line 308 from mouse papilloma; EL-4 cells from mouse lymphoma, radiation-sensitive lymphoma cells, L5178Y-S; radiation-resistant lymphoma cells, L5178y-R. The time interval for the induction of the adaptive response was 4 hrs and 7 hrs. The adaptive response was observed in NL, PK, L929, and L5178y-R, but not in L5178y-5, EL-4, rats-PK, and 308 as determined by cell survival. Apoptosis was also reduced by priming the exposure of low-dose radiation in NL, PK, L929, and L5178y-R cells, when detected using DNA ladder or TUNEL assay. These results suggest that adaptive response by low dose preirradiation is induced in normal or primed cells and apoptosis pathway is involved in these adaptive responses.
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KEYWORD
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Adaptive response, Gamma-ray, Low dose, Apoptosis, Normal cells, Neoplastic cells
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